Cause and Effect Relationship between Candida Spp. and Oral Premalignant Conditions: A Review

ABSTRACT

Oro-pharyngeal malignancy is a critical part of the worldwideweight of disease. The occurrence of oral malignancy isespecially high among men and is the eighth most commoncancer around the world. A significant extent of oral squamouscarcinomas creates from prior potentially malignant disorderof the oral cavity. Etiology of potentially malignant disordersis multifactorial. Tobacco and liquor are viewed as anoteworthy hazard factors however progressively the roleof viral and candidal infection are perceived as being hugein cancer development. Candida spp. is typical commensalfungi that are found colonizing the oral mucosa much of thetime. Oral Candida is "“opportunistic pathogens”. Candidacan switch from a innocuous commensal to the pathogenicorganism which causes oral mucosal infection depending onthe host defense mechanisms or local oral microenvironment.This article highlights the relationship among Candida andoral cancer/PMD.