Serum CRP and Leptin Levels to Assess Nutritional Status in Patients on Maintenance Hemodialysis

ABSTRACT

Introduction: Malnutrition is common in patients withEnd Stage Renal Disease (ESRD) on Hemodialysis (HD).Depending on the parameter measured, the prevalence ofmalnutrition in the chronic dialysis population ranges from 10to 54%. It is related with the secretion of a number of proteins(adipokines), including leptin and adiponectin and alsocytokines such as IL-6. This study was planned with the aimof reviewing the association of nutritional status with serumleptin and CRP levels in hemodialysis patients.Material and methods: The present study was conducted inthe department of Medicine at Chattrapati Shivaji SubhartiHospital from August 2017 to March 2019; consisted of50 patients of End stage Renal Disease on maintenancehemodialysis admitted in Chattrapati Shivaji Subharti Hospitalduring the time period.Results: Out of the 50 subjects, 35 (70%) were male and15 (30%) were females. The Lean Body Mass (%) in thestudy subjects was 59.76±5.92. The overall mean leptinlevel distribution among the subjects was 1.51±0.36. Theoverall mean CRP level distribution among the subjects. was3.75±0.47. A positive correlation was found between CRPand BMI with statistical significance as p<0.05 (table 11).Similarly a highly positive correlation was found betweenLeptin and BMI as p<0.01.Conclusion: Our study point to possible use of serum leptinand CRP concentration as an indicator of nutritional status inHD patients based on observed significant positive correlationbetween serum leptin and CRP concentrations with BMIvalues.