A Retrospective Study of Seroprevalence of Dengue Cases in MGM Medical College, Jamshedpur a Tertiary Care Hospital Of Kolhan Region of Jharkhand

ABSTRACT

Background: Dengue fever and Dengue Haemorrhagic feveris an acute viral disease caused by Dengue virus. The infectionis transmitted by female mosquito- Aedes aegypti. The presentstudy was undertaken to investigate the trend of Dengue andthe seasonal effect associated with it. During late August 2010,outbreak of dengue symptomatic patients was admitted toMGM Medical college hospital Jamshedpur. ELISA for antidengue antibodies confirmed the case as Dengue.Objective: This retrospective study was done to analyze thecirculating dengue virus seroprevalence and seasonal trendamong the patients of the disease who attended to MGMMedical College, Jamshedpur, A tertiary care hospital during2010 to 2015.Methods: It was a hospital-based retrospective studyconducted from September 2010 to December 2015. A total of342 consecutive non-repetitive patients, satisfying the clinicalcase definition of Dengue as per the WHO guidelines, wereincluded in the study. Serum samples were tested for Denguespecific IgM antibodies by NIV Dengue IgM Capture ELISA Kit.Results: Of the 342 patients attended, 110(32.16%) caseswere positive for Dengue IgM antibodies. There was asignificant reduction in the Dengue positivity rate from 31% in2010 to no cases in 2015. The majority of cases occurredduring the monsoon and post-monsoon season.Conclusions: A declining trend of Dengue was seen in thisstudy, however further research work needs to be done to lookfor non-Dengue causes of Dengue fever. Surveillance shouldbe carried out regularly for early detection of an impendingoutbreak and to initiate timely preventive and controlmeasures.