Augmentation of Insulin Secretion Induced by Rhizophora Mucronata and Avicennia Marina Extracts in Streptozotocin-Induced Diabetic Rats
Artículo
| IMSEAR
| ID: sea-203672
ABSTRACT
Background:
Diabetes mellitus is a chronic metabolic disease and is considered as the third leading cause of death in the developedcountries.Objectives:
The aim of this study was to assess the antidiabetic, antioxidant and insulin-enhancing potentials of the aqueous extractsof R. mucronata and A. marina or combination of them. Materials andmethods:
The effects of daily oral administration of aqueous extract fromthe leaves of R. mucronata, A. marina (400 mg/kg BW for each) and combination of both for 6 weeks on streptozotocin-induced diabetic ratswere evaluated considering the blood glucose and insulin levels in the serum. Oxidant/antioxidants status was assessed in the cardiac andmuscular tissues. Immunohistochemical expression of insulin in the pancreatic tissue was also assessed.Results:
Oral administration of theplants extracts alleviated the diabetes-induced changes in serum glucose, insulin and antioxidants status in the heart and muscles compared tothe untreated rats. In addition, these plants enhanced insulin secretion by β-cells of Langerhans as evidence immunohistochemically andbiochemically through calculation of HOMA- β.Conclusion:
The extract of R. mucronata exhibited a promising antidiabetic, antioxidant andinsulin-enhancing effects compared with A. marina extract alone or in combination with R. mucronata.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Año:
2019
Tipo del documento:
Artículo
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