Formulation And Evaluation Of Liquisolid Compacts Of Lornoxicam
Int J Pharm Pharm Sci
;
2019 Jun; 11(6): 33-37
Artículo
| IMSEAR
| ID: sea-205907
ABSTRACT
Objective:
Objective of the present investigation was to enhance the solubility and dissolution rate of poorly water-soluble drug lornoxicam using liquisolid technique with comparative determination of in vitro release profile of liquisolid compacts and conventional formulation of lornoxicam.Methods:
Formulation was prepared by a liquisolid technique using different drug concentration in a liquid vehicle and different carrier/coating ratio. Prepared liquisolid compact was evaluated for Fourier transform infrared (FTIR) spectra analysis, differential scanning calorimetry (DSC), X-ray diffraction (P-XRD), scanning electron microscopy (SEM) and in vitro dissolution study.Results:
The result showed that liquisolid compacts of lornoxicam displayed significantly higher drug release rate as compared to pure drug and conventional tablet prepared. The results of both DSC and X-ray crystallography indicated loss of crystallinity of the drug upon formulated into the liquisolid compact.Conclusion:
Dissolution rate of the drug from liquisolid compacts was affected by changing the drug concentration and excipient ratio. The liquisolid technique appeared to be a promising approach for improving the dissolution of poorly soluble drug lornoxicam.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Revista:
Int J Pharm Pharm Sci
Año:
2019
Tipo del documento:
Artículo
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