Effect of hydroxyurea on foetal haemoglobin in myeloproliferative & myelodysplastic syndromes.

Advani, S H; Venugopal, P; Charak, B S; Das Gupta, A; Mazumdar, A T; Gopal, R; Nair, C N; Saikia, T K; Nadkarni, K S; Kurkure, P A

Advani, S H; Venugopal, P; Charak, B S; Das Gupta, A; Mazumdar, A T; Gopal, R; Nair, C N; Saikia, T K; Nadkarni, K S; Kurkure, P A.

Artículo en Inglés | IMSEAR | ID: sea-20895

ABSTRACT

ABSTRACT

The effect of hydroxyurea on foetal haemoglobin (HbF) levels was evaluated in 36 patients of myeloproliferative and myelodysplastic disorders. In 17 (47.2%) patients, HbF levels increased from 1.40 +/- 1.17 to 3.03 +/- 1.97 per cent after 4 wk therapy with hydroxyurea. In the responders this increase was highly significant (P less than 0.001). The rise in the HbF levels after hydroxyurea therapy was significant in patients with chronic myeloid leukaemia but not in the other groups.

Asunto(s)

Adolescente; Adulto; Anciano; Niño; Femenino; Hemoglobina Fetal/análisis; Humanos; Hidroxiurea/farmacología; Masculino; Persona de Mediana Edad; Síndromes Mielodisplásicos/sangre; Trastornos Mieloproliferativos/sangre

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Síndromes Mielodisplásicos / Anciano / Femenino / Humanos / Masculino / Hemoglobina Fetal / Niño / Adolescente / Adulto / Hidroxiurea Idioma: Inglés Año: 1990 Tipo del documento: Artículo

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