Advances in Protein Characterization by High-Resolution Mass Spectrometry

High-resolution mass spectrometry has become an indispensable tool for a variety of biological research areas, includingprotein chemistry. The coupling of electrospray ionization to the MS has revolutionized the approaches for the identification ofnew proteins. Some examples of these applications include the identification of proteins involved in the virulence of pathogenicbacterial strains. MS played an important role in advancing protein folding studies, identification of new biomarkers for thedetection of diseases in early stages. A recent development in MS technique called fast photochemical oxidation of proteinssignificantly advanced the protein structural analysis.