GDF -15 and Severity Scores in Sickle Cell Disease Patients Attending Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria
Artículo
| IMSEAR
| ID: sea-210340
ABSTRACT
Aim:
Granulocyte differentiation factor 15 (GDF15) is a growth factor andbiomarker for many disorders where Ischaemia Reperfusion Injury (IRI) is pathophysiologically relevant. Hence theneed to evaluate GDF-15 as a biomarker inSickle Cell Disease (SCD).StudyDesign:
This is a cross sectional study.Place and Duration of Study Department of Haematology, Nnamdi University Teaching Hospital, Nnewi, Anambra state, Nigeria, between January and December 2018.Methods:
Ninety subjects were randomly recruitedwith haemoglobin (Hb) phenotypesSS (test),AS and AA (controls); numbering30,28and 32 respectively. Disease severity was determined by calculating an objective score. 5 mls of blood was collectedandused to determine Full Blood Count (FBC),haemoglobin Phenotype andGDF-15 levels(byEnzymeLinked Immunosorbent assay).Data collected was analysed using Statistical Package for Social Sciences software version 20 (SPSS Inc., IL, Chicago, USA). P< 0.05 was considered as significant.Results:
GDF-15 level was found to be significantly differentin the different HB phenotypes p= 0.005 and correlated negatively with sickle cell disease severity (r= -0.307, p= 0.098). The difference betweenmedianGDF-15 levels of HBSS subjects with mild and moderate disease was statistically significant at p= 0.01.Conclusion:
We hypothesize that GDF-15 maybeapotential therapeutic target for intervention against ischaemia/reperfusion inducedmicro-vascularinjury.Natural GDF-15 mimetics maybe useful in taking advantage of this potential therapeutic target.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Tipo de estudio:
Estudio observacional
Año:
2020
Tipo del documento:
Artículo
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