Nestin is significantly associated with the overall survival of nonsmall cell lung cancer: A meta-analysis
J Cancer Res Ther
;
2020 Sep; 16(4): 800-803
Artículo
| IMSEAR
| ID: sea-213705
ABSTRACT
Aims:
Some studies investigated the association between nestin and the overall survival (OS) of nonsmall cell lung cancer (NSCLC). However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis to determine the association between nestin and OS of NSCLC. Materials andMethods:
PubMed and EMBASE were searched to find relevant studies. The strength of the association was calculated with the hazard ratios (HRs) and respective 95% confidence intervals (CIs).Results:
High expression of nestin was significantly associated with OS of NSCLC (HR = 2.09; 95% CI = 1.59–2.77). In the stratified analysis by race, we found that the expression of nestin was significantly associated with OS of NSCLC in Asians (HR = 3.02; 95% CI = 1.80–5.07) and Caucasians (HR = 1.81; 95% CI = 1.21–2.71). In addition, when we limited the meta-analysis to studies that controlled for clinical parameters, a significant association between nestin and OS of NSCLC remained (HR = 2.19; 95% CI = 1.54–3.11). A sensitivity analysis showed no substantial modification of the estimates after exclusion of individual studies.Conclusions:
In conclusion, this meta-analysis suggested that high expression of nestin was significantly associated with OS of NSCLC.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Tipo de estudio:
Revisiones Sistemáticas Evaluadas
Revista:
J Cancer Res Ther
Asunto de la revista:
Neoplasms
/
Therapeutics
Año:
2020
Tipo del documento:
Artículo
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