Co-Existence of Chronic Lymphocytic Leukaemia and Malignancy of Uterine Cervix

ABSTRACT

Chronic Lymphocytic Leukaemia (CLL) is the most common variety of leukaemia. In this disease B-lymphocytes which would normally respond to antigens by transformation and forming antibodies, fail to do so. Patients with chronic lymphocytic leukaemia have up to a threefold risk of site specific secondary cancers. However, the co-existence of chronic lymphocytic leukaemia with gynaecological cancers is a rare phenomenon. Expert clinical and pathological review is warranted for proper diagnosis and management. Here we report a case of 57 year old patient with co-existent CLL and squamous cell carcinoma of the uterine cervix.Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia affecting the western world. It occurs mostly in the elderly.[1] It is less frequent in the Asian population. CLL is characterized by clonal proliferation and accumulation of mature, typically, CD5 positive B-cells within the bone marrow, spleen, blood and lymph nodes.[2]