Dermostatin A and B: chromatography, structural and configurational studies using HPLC, CCD, 13C (125 MHz) and 1H (500 MHz) NMR spectroscopy.
Hindustan Antibiot Bull
;
1994 Feb-May; 36(1-2): 6-20
Artículo
en Inglés
| IMSEAR
| ID: sea-2200
ABSTRACT
HPLC of crude Dermostatin indicated presence of three pairs of components. Hence, attempts were made to purify Dermostatin. Purification of crude Dermostatin has been carried out using column chromatography and counter current distribution methods. Each of these fractions were tested for activity. The major fraction which showed greater activity was taken for the preparation of Dermostatin nona-acetate. Structural characterisation of Dermostatin nona-acetate has been carried out using UV-visible spectroscopy in different solvents to obtain the characteristic spectrum of a carbonyl conjugated hexaene at room temperature. Structural and configurational studies of Dermostatin nona-acetate using 500 MHz 1H NMR and 125 MHz 13C NMR has been used in the assignment of various functional groups in Dermostatin A and B as well as to provide corroboration to the earlier structural elucidation.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Polienos
/
Espectroscopía de Resonancia Magnética
/
Cromatografía Líquida de Alta Presión
/
Distribución en Contracorriente
/
Conformación Molecular
/
Antifúngicos
Idioma:
Inglés
Revista:
Hindustan Antibiot Bull
Año:
1994
Tipo del documento:
Artículo
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