Group B Streptococcal Colonization among Pregnant Women and Neonates in a Tertiary Care Hospital in South India

Objectives To assess the prevalence of maternal and neonatal group B Streptococcal colonization, incidence of neonatal systemic illness, and antibiotic sensitivity of isolates. Methods This prospective cohort study was conducted in a South Indian tertiary care hospital. Rectovaginal swabs from pregnant mothers at 360/7–376/7 wk gestation and throat and rectal swabs from their neonates at 48 h of age were collected. Presence of group B Streptococcus (GBS) was identifed by broth enrichment step, and traditional microbiologic methods and antibiotic sensitivity of isolates was noted. All mothers received intrapartum antibiotic prophylaxis (IAP). Culture-positive sepsis, clinical sepsis, pneumonia, meningitis, and urinary tract infection were defned as neonatal systemic illness. Neonates of colonized mothers were followed at 3 mo for late-onset sepsis. Results Of the 310 mothers, 40 were GBS colonized (prevalence: 12.9%; 95% CI 9.2%, 17.6%). None of the neonates were colonized. Maternal GBS colonization was signifcantly associated with premature rupture of membrane (RR - 2.93, 95% CI - 1.66–5.16) and neonatal systemic illness (RR - 2.78, 95% CI - 1.39–5.54). Positive correlation was noted between duration of IAP?4 h and neonatal illness and between maternal GBS colonization and Apgar at 1 min?4. Clindamycin resistance was noted in 20%. All neonates remained well at 3 mo follow-up. Conclusion High maternal colonization alerts the need for GBS screening in India. Clindamycin resistance among GBS isolates questions its efectiveness as alternative therapy in penicillin allergy.