Gonadotropin-Dependent Precocious Puberty: Single-Center Experience From Western India
Indian Pediatr
;
2023 Jun; 60(6): 463-466
Artículo
| IMSEAR
| ID: sea-225428
ABSTRACT
Objective:
To describe the characteristics of gonadotropin-dependent precocious puberty (GDPP) in Indian children.Methods:
Clinical profiles of GDPP (n=78, 61 females) and premature thelarche (n=12) from a single center in Western India were retrospectively studied.Results:
Pubertal onset was earlier in boys than girls (29 vs 75 months, respectively; P=0.008). The basal luteinizing hormone (LH) was ?0.3 mIU/mL, except 18% of GDPP girls. At 60 minutes after GnRHa-stimulation, all patients (except one girl) had LH ?5 mIU/mL. The GnRHa-stimulated LH/FSH ratio was ?0.34 at 60 minutes in girls with GDPP unlike premature thelarche. Only one girl had an allergic reaction to long-acting GnRH agonist. Among GnRH agonist-treated girls (n=24), the predicted final adult height was -1.67±1.5 SDS, whereas the attained final height was -0.25±1.48 SDS.Conclusion:
We establish the safety and efficacy of long acting GnRH agonist therapy in Indian children with GDPP. The 60-minute stimulated serum LH/FSH of ?0.34 differentiated GDPP from premature thelarche.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Revista:
Indian Pediatr
Año:
2023
Tipo del documento:
Artículo
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