A new horizon in Stargardt’s disease: a comprehensive rapid review of interventional therapies

This rapid synthesis comprised seven studies on inherited macular dystrophy, known as Stargardt disease, which primarily affects children and young adults and is caused by the breakdown of a particular type of light-sensing cell in the eye called ABCA4. One database was selected, and search was carried out using the keywords Stargardt disease and interventional techniques by the application of the appropriate inclusion and exclusion criteria. Most studies were randomized controlled trials, and other systematic reviews and meta-analyses were included, which provided information about the study's methodology and results. The interventional therapies used in this review, including the use of saffron, docosahexaenoic acid, emuxistat hydrochloride, and biofeedback therapy, had a positive effect on Stargardt disease. Therefore, additional studies and syntheses, including controlled trials, case series, adequate sample sizes, and multiple centers, are needed in the future.