Synthesis, physico-chemical and biological properties of some alkali metals and quaternary alkylammonium salts of polyene antibiotics: amphotericin B, nystatin and aureofungin.
Hindustan Antibiot Bull
;
1994 Feb-May; 36(1-2): 34-8
Artículo
en Inglés
| IMSEAR
| ID: sea-2430
ABSTRACT
Polyene antibiotics are known for their remarkable antifungal properties. The alkali metal and quaternary alkylammonium salts of amphotericin B, nystatin and aureofungin have been prepared by ion-exchange method. The physico-chemical and biological properties of these salts have been studied with a view to evaluate their therapeutic advantages over the parent compounds. While the majority of the salts reported herein showed more water solubility; triethylammonium salts, unlike the other alkali metal salts, possessed marginally improved or similar bioactivity in comparison to their parent antibiotic having reduced toxicity.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Polienos
/
Candida albicans
/
Química Física
/
Anfotericina B
/
Nistatina
/
Fenómenos Químicos
/
Compuestos de Amonio Cuaternario
/
Metales
/
Antifúngicos
Idioma:
Inglés
Revista:
Hindustan Antibiot Bull
Año:
1994
Tipo del documento:
Artículo
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