Granulocyte macrophage colony stimulating factor augmented hepatitis B vaccine protocol for rapid seroprotection in voluntary kidney donors.
Artículo
en Inglés
| IMSEAR
| ID: sea-25099
ABSTRACT
BACKGROUND & OBJECTIVES:
Conventional hepatitis B vaccine protocols do not provide rapid seroprotection against hepatitis B. This randomized controlled trial was carried out to investigate the efficacy of granulocyte macrophage-colony stimulating factor (GM-CSF) augmented double-dose vaccine protocol in voluntary kidney donors prior to donor nephrectomy.METHODS:
A total of 54 kidney donors, who had no history of hepatitis B infection, hepatitis B vaccination and tested negative for anti-HBs and anti-HBc antibodies were randomly allocated to the control or test groups. GM-CSF (300 microg) was administered subcutaneously on day 0, followed by 40 microg of recombinant hepatitis B vaccine intramuscularly on the same deltoid on day 1. The control group received only 40 microg of intramuscular hepatitis B vaccine. Anti-HBs titres were measured at the end of 4 wk.RESULTS:
Of the 54 donors studied, there was a significant (P<0.003) seroconversion in the GM-CSF group (82%) compared to the control group (37%), after a single immunization with double-dose recombinant hepatitis B vaccine by 4 wk. Minor side effects such as fever in four patients and myalgia in three were noticed. INTERPRETATION &CONCLUSION:
GM-CSF augmented double-dose hepatitis B vaccine could be used in unvaccinated patients when a rapid response is desired.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Factores de Tiempo
/
Donantes de Tejidos
/
Femenino
/
Humanos
/
Masculino
/
Adyuvantes Inmunológicos
/
Factor Estimulante de Colonias de Granulocitos y Macrófagos
/
Trasplante de Riñón
/
Vacunas contra Hepatitis B
/
Adulto
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Año:
2004
Tipo del documento:
Artículo
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