Synthetic peptides related to the delta-receptor agonist, dermorphin gene associated peptide.
Indian J Biochem Biophys
;
1995 Aug; 32(4): 196-9
Artículo
en Inglés
| IMSEAR
| ID: sea-26370
ABSTRACT
The delta-receptor selective dermorphin gen associated peptide (DGAP) and five of its analogues having structural modifications at positions 2, 4 and 5 were synthesized by the solid phase method using 9-fluorenylmethoxycarbonyl amino acid trichlorophenyl esters as coupling agents and rho-benzyloxybenzyl alcohol resin as the solid support. The delta-receptor selectivity of these peptides was determined by guinea pig ileum and mouse vas deferens assays. The latter assay was carried out using modified Kreb's solution aerated with pure oxygen instead of carbogen. All the synthetic peptides were found to be delta-receptor selective.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Oligopéptidos
/
Péptidos
/
Bioensayo
/
Masculino
/
Datos de Secuencia Molecular
/
Secuencia de Aminoácidos
/
Receptores Opioides delta
/
Cobayas
/
Animales
/
Ratones
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1995
Tipo del documento:
Artículo
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