Interaction of chlorpromazine with hemoglobin.
Indian J Biochem Biophys
;
1990 Aug; 27(4): 240-4
Artículo
en Inglés
| IMSEAR
| ID: sea-26377
ABSTRACT
Binding of chlorpromazine (CPZ), a widely used antidepressant tranquilizer, with hemoglobin has been studied by equilibrium dialysis method. r/Cf versus r plot was typically concave downwards revealing the positive cooperative nature of binding. Binding parameters, namely the affinity constant (K) and the degree of cooperativity (nH) were determined from the Hill plot. Oxygen was found to be released gradually from hemoglobin with gradual addition of CPZ, the extent of oxygen release depending on the stoichiometric ratio of CPZ hemoglobin (D/P).
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Oxígeno
/
Sitios de Unión
/
Humanos
/
Hemoglobinas
/
Cinética
/
Clorpromazina
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1990
Tipo del documento:
Artículo
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