Molecular electrostatic potential mapping and structure-activity relationship for 3-methoxy flavones.
Indian J Biochem Biophys
;
1996 Dec; 33(6): 458-64
Artículo
en Inglés
| IMSEAR
| ID: sea-26487
ABSTRACT
Molecular electrostatic potential (MEP) maps of certain 3-methoxy flavone derivatives having different anti-picornavirus activities have been studied. Geometries of the molecules were optimised and charge distributions computed using the AM1 molecular orbital method. Hybridization displacement charges (HDC) were combined with the Löwdin charge distributions to compute the MEP maps. Reliability of the method of computing MEP maps was tested by studying certain other molecules for which ab initio MEP results are available. The anti-picornavirus activities of the flavones have been shown to be related with negative MEP values in two regions, one near the 3-methoxy group and another in a diagonally opposite region near the substituent attached to the C7 atom of the molecules.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Antivirales
/
Picornaviridae
/
Relación Estructura-Actividad
/
Flavonoides
/
Estructura Molecular
/
Química Física
/
Electricidad Estática
/
Fenómenos Químicos
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1996
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS