Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes.
Indian J Biochem Biophys
;
1991 Apr; 28(2): 136-9
Artículo
en Inglés
| IMSEAR
| ID: sea-26495
ABSTRACT
The microsomal membranes isolated from rat testes have been found to contain a Mg(2+)-dependent and a Mg(2+)-independent Ca(2+)-ATPase. The enzyme activities were inhibited by two contraceptive drugs--gossypol and chlorpromazine. The inhibition by the former was affected by the presence of ligand(s) and not the substrate in the incubation medium, whereas ligand(s)/substrate did not affect the inhibition by chlorpromazine. This may be explained from the fact that the binding of chlorpromazine and ligand(s)/substrate to the enzyme are independent of each other whereas in case of gossypol the ligand(s) compete with the drug at the binding site of the enzyme.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Testículo
/
Masculino
/
Gosipol
/
Cinética
/
Clorpromazina
/
ATPasa de Ca(2/) y Mg(2/)
/
ATPasas Transportadoras de Calcio
/
Membranas Intracelulares
/
Animales
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1991
Tipo del documento:
Artículo
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