Oral and parenteral immunization with synthetic retro-inverso peptides induce antibodies that cross-react with native peptides and parent antigens.
Indian J Biochem Biophys
;
2007 Jun; 44(3): 140-4
Artículo
en Inglés
| IMSEAR
| ID: sea-26545
ABSTRACT
The objective of this study was to determine whether certain retro-inverso peptides have the potential to act as synthetic vaccines in mice, when immunized by injection or orally. Immunization of mice parenterally with conjugates of three such retro-inverso peptides and orally with the unconjugated peptides elicited generally high titres of anti-peptide antibodies. Antibodies against the same three peptides cross-reacted by binding strongly in ELISA to the native peptides and vice versa, regardless of the mode of immunization. Antibodies against a retro-inverso diphtheria peptide also reacted strongly with diphtheria toxin. Seven of 8 mice, immunized by injection of the conjugate of a retro-inverso derivative of robustoxin [a lethal spider (Atrax robustus) venom toxin] were protected from challenge involving injection with twice the minimum lethal dose of A. robustus venom containing the toxin.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Péptidos
/
Plasmodium falciparum
/
Serina
/
Venenos de Araña
/
Ensayo de Inmunoadsorción Enzimática
/
Vacunas Sintéticas
/
Adyuvantes Inmunológicos
/
Administración Oral
/
Inmunización
/
Vacunación
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
2007
Tipo del documento:
Artículo
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