Alterations in brain tumor DNA detected by a fingerprinting probe.
Indian J Biochem Biophys
;
1996 Dec; 33(6): 455-7
Artículo
en Inglés
| IMSEAR
| ID: sea-26769
ABSTRACT
We used a novel DNA fingerprinting probe O-chi-1 (ref. 1) to detect differences in the hybridization pattern of brain tumor DNA and paired normal tissue of a given individual. Representatives of meningiomas (two), glioblastoma multeforme (three) and astrocytoma (one) were studied. Alterations, which included amplification as well as the loss of a normal band in tumor DNA, were observed in four of the six tumours. While the increased intensity of a band can be taken to imply increased copy number, the disappearance of bands could either be due to loss of DNA sequence or rearrangement resulting in different sized bands.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Astrocitoma
/
Neoplasias Encefálicas
/
Humanos
/
ADN de Neoplasias
/
Desoxirribonucleasas de Localización Especificada Tipo II
/
Sondas de ADN
/
Southern Blotting
/
Dermatoglifia del ADN
/
Glioblastoma
/
Electroforesis en Gel de Agar
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1996
Tipo del documento:
Artículo
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