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Further characterization of negative regulatory element involved in the hormonal regulation of GlcNAc-1-P transferase gene in mouse mammary gland.
Indian J Biochem Biophys ; 1997 Feb-Apr; 34(1-2): 110-7
Artículo en Inglés | IMSEAR | ID: sea-26880
ABSTRACT
The gene encoding UDP-GlcNAcdolichol phosphate N-acetylglucosamine-1-phosphate transferase (GPT), the enzyme that initiates the pathway for the biosynthesis of asparagine-linked glycoproteins, is ubiquitously expressed in eukaryotic cells. However, its expression in the mammary gland is developmentally and hormonally regulated; transcription of the mouse mammary GPT gene is stimulated by the lactogenic hormones, insulin, glucocorticoid, and prolactin. Earlier, we demonstrated that a distal negative regulatory element in mouse GPT (mGPT) promoter plays an important role in developmental and hormonal control of mGPT gene expression in mammary gland (Ma J, Saito H, Oka T and Vijay IK (1996) J Biol Chem, in press). In this report, a tissue distribution of the repressor that binds the negative regulatory element was examined; a comparison of the negative regulatory element to other consensus sequences for known transcription factors is discussed.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Oligodesoxirribonucleótidos / Proteínas Represoras / Femenino / Secuencia de Bases / Regulación Enzimológica de la Expresión Génica / Genes Reguladores / Regiones Promotoras Genéticas / Transferasas (Grupos de Otros Fosfatos Sustitutos) / Animales / Glándulas Mamarias Animales Idioma: Inglés Revista: Indian J Biochem Biophys Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Oligodesoxirribonucleótidos / Proteínas Represoras / Femenino / Secuencia de Bases / Regulación Enzimológica de la Expresión Génica / Genes Reguladores / Regiones Promotoras Genéticas / Transferasas (Grupos de Otros Fosfatos Sustitutos) / Animales / Glándulas Mamarias Animales Idioma: Inglés Revista: Indian J Biochem Biophys Año: 1997 Tipo del documento: Artículo