Further characterization of negative regulatory element involved in the hormonal regulation of GlcNAc-1-P transferase gene in mouse mammary gland.
Indian J Biochem Biophys
;
1997 Feb-Apr; 34(1-2): 110-7
Artículo
en Inglés
| IMSEAR
| ID: sea-26880
ABSTRACT
The gene encoding UDP-GlcNAcdolichol phosphate N-acetylglucosamine-1-phosphate transferase (GPT), the enzyme that initiates the pathway for the biosynthesis of asparagine-linked glycoproteins, is ubiquitously expressed in eukaryotic cells. However, its expression in the mammary gland is developmentally and hormonally regulated; transcription of the mouse mammary GPT gene is stimulated by the lactogenic hormones, insulin, glucocorticoid, and prolactin. Earlier, we demonstrated that a distal negative regulatory element in mouse GPT (mGPT) promoter plays an important role in developmental and hormonal control of mGPT gene expression in mammary gland (Ma J, Saito H, Oka T and Vijay IK (1996) J Biol Chem, in press). In this report, a tissue distribution of the repressor that binds the negative regulatory element was examined; a comparison of the negative regulatory element to other consensus sequences for known transcription factors is discussed.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Oligodesoxirribonucleótidos
/
Proteínas Represoras
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Femenino
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Secuencia de Bases
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Regulación Enzimológica de la Expresión Génica
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Genes Reguladores
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Regiones Promotoras Genéticas
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Transferasas (Grupos de Otros Fosfatos Sustitutos)
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Animales
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Glándulas Mamarias Animales
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1997
Tipo del documento:
Artículo
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