Current status of ribosome inactivating proteins.
Indian J Biochem Biophys
;
2000 Feb; 37(1): 1-5
Artículo
en Inglés
| IMSEAR
| ID: sea-27136
ABSTRACT
Ribosome inactivating proteins (RIPs) are a group of naturally occurring plant proteins with a RNA-N-glycosidases activity which depurinate rRNA at a specific universally conserved position (i.e. cleavage of N-glycosidic bond of a specific adenine of 28S rRNA). These proteins are found in different parts of plants, in concentrations ranging from a few micrograms to several hundred mg per 100 g of plant tissues. RIPs exist in two forms, type 1 having a single polypeptide chain with a molecular mass of approximately 30 kDa possessing N-glycosidase activity; and type 2 with two or four polypeptide chains having a molecular mass of approximately 60 kDa and approximately 120 kDa respectively showing lectin activity along with N-glycosidase moiety. Such biomolecules causing cytotoxicity are being exploited for designing immunotoxins/hormonotoxins using heterobifunctional conjugates. These carrier conjugates with the RIPs can influence cellular trafficking and inhibition of protein synthesis. We are witnessing a novel protein from plants that can be utilised for various therapeutical treatments ranging from cancers, AIDS and other viral diseases of present times.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Proteínas de Plantas
/
Ribosomas
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
2000
Tipo del documento:
Artículo
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