Contribution of genomics and proteomics in understanding the role of modifying factors in Parkinson's disease.
Indian J Biochem Biophys
;
2006 Apr; 43(2): 69-81
Artículo
en Inglés
| IMSEAR
| ID: sea-27444
ABSTRACT
Parkinson's disease (PD) is a complex neurological disorder, characterized by selective degeneration of nigrostriatal dopaminergic neurons. It is a multi-factorial disease, contributed by a combination of age, genetic and environmental factors. Etiology of sporadic PD and mechanism underlying selective loss of dopaminergic neurons has not yet been clearly understood. Recent developments in genomics and proteomics have revolutionized the research on PD at genetic level. Differential gene expression patterns (DNA biochip technology), age-dependent complex genetic patterns (SNP genotyping), and protein expression profiles (proteomics) of PD patients have started providing the specific and rigorous molecular explanation and role of modifying factors in PD. Genomics and proteomics are further expected to help in developing biomarkers for diagnosis of early onset PD and also to develop valuable and potential therapeutic strategies for its treatment. In this review, we have discussed the progress made by genomics and proteomics, in understanding the role of modifying factors in PD.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Enfermedad de Parkinson
/
Humanos
/
Análisis de Secuencia por Matrices de Oligonucleótidos
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Polimorfismo de Nucleótido Simple
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Genómica
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Proteómica
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Animales
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
2006
Tipo del documento:
Artículo
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