Conjugation of proteins and enzymes with hydrophilic polymers and their applications.
Indian J Biochem Biophys
;
1991 Oct-Dec; 28(5-6): 346-51
Artículo
en Inglés
| IMSEAR
| ID: sea-27646
ABSTRACT
The efficacy of a number of therapeutically active proteins and peptides is severely limited due to their instability in circulation. Of the various approaches used to stabilise these proteins, the one more successful is covalent modification of the protein or enzyme with some hydrophilic polymers such as dextran or PEG. These conjugates are more stable than the native protein both in vitro as well as in vivo. They exhibit enhanced resistant to proteolytic degradation, have a long-life in circulation and exhibit reduced immunogenicity. The therapeutic efficacy of these conjugates is also greatly enhanced compared to the native protein or enzyme.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Polietilenglicoles
/
Humanos
/
Proteínas
/
Dextranos
/
Estabilidad de Medicamentos
/
Enzimas
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1991
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS