Relationship of single-stranded DNA-binding proteins of Ehrlich ascites tumour to cell growth phase and DNA replications.
Indian J Biochem Biophys
;
1992 Feb; 29(1): 9-12
Artículo
en Inglés
| IMSEAR
| ID: sea-27947
ABSTRACT
The possible involvement of SSB-proteins in DNA replication in Ehrlich ascites tumour (EAT) has been investigated. A direct relation (the computer-generated correlation coefficient was 0.9) between the SSB-proteins content in chromatin and intensity of the replicative synthesis of DNA in various preparation of EAT in vivo and in vitro is observed. Addition of exogenous SSB-proteins to the permeable EAT cells has been found to increase the replicative synthesis. Although eukaryotic SSB-proteins are not complete analogs of the prokaryotic SSB-proteins, they evidently participate in DNA replication in eukaryotic cells and possibly are intracellular regulators of proliferation.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Masculino
/
ADN de Cadena Simple
/
Carcinoma de Ehrlich
/
División Celular
/
Proteínas de Unión al ADN
/
Replicación del ADN
/
Animales
/
Ratones
/
Proteínas de Neoplasias
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1992
Tipo del documento:
Artículo
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