Conformations of deoxydinucleoside phosphates containing pyrimidine-pyrimidine photodimers.
Indian J Biochem Biophys
;
1990 Jun; 27(3): 130-5
Artículo
en Inglés
| IMSEAR
| ID: sea-28334
ABSTRACT
Conformational analysis of deoxydinucleoside monophosphates with the sequences TpT and CpC have been carried out with the incorporation of both cyclobutane type pyrimidine dimers and 6-4 photoadducts using the methods of molecular mechanics energy minimization. The effect of flexibility with respect to sugar geometries and glycosidic torsions have been studied and the relative energies of a large variety of structures have been compared. The salient features obtained from these calculations have been compared with the crystallographic and spectroscopic data on pyrimidine dimer incorporated deoxydinucleoside monophosphates. Effects of "inserting" the energetically favourable conformations of such structures into B-DNA helices have been discussed in terms of the distortions in helical structures.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Dímeros de Pirimidina
/
Termodinámica
/
Timidina
/
Fosfatos de Dinucleósidos
/
Modelos Moleculares
/
Citidina
/
Conformación de Ácido Nucleico
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1990
Tipo del documento:
Artículo
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