IRF-1 and IRF-2 as regulators of the interferon system and cell growth.
Indian J Biochem Biophys
;
1995 Oct; 32(5): 235-9
Artículo
en Inglés
| IMSEAR
| ID: sea-28347
ABSTRACT
Interferons (IFNs) are families of cytokines which have been discovered and extensively characterized in the context of host defense against viral infections. We have discovered two structurally related transcription factors, Interferon regulatory factor-1 (IRF-1) and IRF-2. These two factors, however, function not only as regulators of the IFN system, but are also key transcription factors in the regulation of cell cycle and apoptosis. These studies uncover a complex gene transcription network, by which the fate of cellular responses are determined depending on how the IRF transcription factors function in conjunction with other factors, and on the promoters of distinct genes under different conditions of the cells.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fosfoproteínas
/
Proteínas Represoras
/
Factores de Transcripción
/
Humanos
/
División Celular
/
Interferones
/
Proteínas de Unión al ADN
/
Factor 1 Regulador del Interferón
/
Factor 2 Regulador del Interferón
/
Animales
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1995
Tipo del documento:
Artículo
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