Mode of action of intercalators: a theoretical study.
Indian J Biochem Biophys
;
1990 Aug; 27(4): 228-39
Artículo
en Inglés
| IMSEAR
| ID: sea-28437
ABSTRACT
Mode of action of some intercalators has been theoretically investigated on the basis of quantum mechanical perturbation method. Energies of H-bond interaction between drug chromophore and base pairs have been calculated in all possible orientations. The stacking energy has also been calculated with the base pairs. The effect of these interactions on specific recognition has also been discussed. On the basis of these studies, a model for the interaction of these drugs has been proposed. This explains the relative activities of acridine intercalators and satisfies the experimental observations.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Termodinámica
/
Composición de Base
/
Ácidos Nucleicos
/
Enlace de Hidrógeno
/
Sustancias Intercalantes
/
Modelos Químicos
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1990
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS