Metabolism of 5-aminoquinoline with liver cytosol enzyme.
Indian J Biochem Biophys
;
1993 Aug; 30(4): 229-33
Artículo
en Inglés
| IMSEAR
| ID: sea-28724
ABSTRACT
In vitro oxidation and acetylation of 5-aminoquinoline by rabbit liver enzyme preparation has been investigated. Incubation of 5-aminoquinoline with cytosol fraction of the enzyme preparation in the presence of acetyl coenzyme-A gave rise to three different products, viz. 5-amino-2-hydroxy quinoline, 5-acetyl-aminoquinoline and 5-acetylamino-2-hydroxy quinoline due to the combined action of aldehyde oxidase and N-acetyl transferase. The metabolites thus obtained by enzyme catalysed reactions were isolated and separated by TLC, HPLC and subsequently characterised by IR and mass spectral fragmentation techniques.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Oxidación-Reducción
/
Acetilación
/
Conejos
/
Acetiltransferasas
/
Espectrometría de Masas
/
Femenino
/
Cinética
/
Biotransformación
/
Cromatografía Líquida de Alta Presión
/
Cromatografía en Capa Delgada
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1993
Tipo del documento:
Artículo
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