Gramicidin channels--a solvable membrane "protein" folding problem.
Indian J Biochem Biophys
;
1996 Oct; 33(5): 331-42
Artículo
en Inglés
| IMSEAR
| ID: sea-28736
ABSTRACT
The linear gramicidins are peptide antibiotics that form cation-selective channels in lipid bilayers. Gramicidin channels have very well-defined functional characteristics, and the structure of membrane-spanning gramicidin A channels is known at atomic resolution. These features make the gramicidins well suited to study how the amino acid sequence encodes the structure and function of a membrane-spanning channel. We show how one can use electrophysiological measurements to obtain structural information about conducting channels and to quantify the conformational preferences of sequence-substituted gramicidin mutants.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Conformación Proteica
/
Datos de Secuencia Molecular
/
Modelos Moleculares
/
Secuencia de Aminoácidos
/
Pliegue de Proteína
/
Gramicidina
/
Canales Iónicos
/
Membrana Dobles de Lípidos
/
Proteínas de la Membrana
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1996
Tipo del documento:
Artículo
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