Modulation of mRNA levels of liver arginase by insulin and vanadate in experimental diabetes.
Indian J Biochem Biophys
;
1999 Apr; 36(2): 125-8
Artículo
en Inglés
| IMSEAR
| ID: sea-28805
ABSTRACT
This work was carried out to study the modulation of arginase expression in experimental diabetes. Here, we have demonstrated that liver arginase activity and mRNA levels increased significantly in diabetic condition. Insulin treatment reverses the increased activity and mRNA levels nearly to the control values. The reversal effects of vanadate are found to be similar to that of insulin and this observation further reiterates the insulin-like effects of vanadate. ELISA and slot blot assay observations are consistent with biochemical measurements of enzyme activity. These results show an increase in arginase activity and mRNA levels in diabetes and decrease in treated animals may be due to the transcriptional regulation of arginase gene.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Arginasa
/
Ratas
/
Femenino
/
ARN Mensajero
/
Vanadatos
/
Ratas Wistar
/
Diabetes Mellitus Experimental
/
Insulina
/
Hígado
/
Animales
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1999
Tipo del documento:
Artículo
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