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Photosensitization of cultured cells and viruses by pyrene lipids.
Indian J Biochem Biophys ; 1990 Dec; 27(6): 359-62
Artículo en Inglés | IMSEAR | ID: sea-28852
ABSTRACT
Administration of pyrene-linked fatty acids and lipids to cultured cells or an enveloped (vesicular stomatitis) virus induced photosensitization which, following irradiation with a long ultra-violet light (LUV), resulted in killing of the cells and loss of the infectivity of the virus with the following specific effects. (i) LUV illumination of the pyrene-sphingomyelin administered cultured skin fibroblasts derived from normal individuals and patients with Niemann-Pick disease permitted selective killing of the latter. (ii) Similarly LUV illumination of pyrenedodecanoic acid (P12) incubates of leukemic cell lines mixed with human bone marrow cells permitted selective killing of the former. (iii) LUV illumination of P12 incubates of vesicular stomatitis virus decreased the infectivity of the virus by up to 12 logs.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Pirenos / Esfingomielinas / Rayos Ultravioleta / Células Tumorales Cultivadas / Leucemia Mieloide / Supervivencia Celular / Células Cultivadas / Enfermedades de Niemann-Pick / Virus de la Estomatitis Vesicular Indiana / Fibroblastos Idioma: Inglés Revista: Indian J Biochem Biophys Año: 1990 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Pirenos / Esfingomielinas / Rayos Ultravioleta / Células Tumorales Cultivadas / Leucemia Mieloide / Supervivencia Celular / Células Cultivadas / Enfermedades de Niemann-Pick / Virus de la Estomatitis Vesicular Indiana / Fibroblastos Idioma: Inglés Revista: Indian J Biochem Biophys Año: 1990 Tipo del documento: Artículo