Membrane instability in respiring mitochondria: role of phosphate.
Indian J Biochem Biophys
;
1992 Apr; 29(2): 103-14
Artículo
en Inglés
| IMSEAR
| ID: sea-28883
ABSTRACT
Metabolically-induced (spontaneous) high amplitude swelling of mitochondria has been shown to be due to a serial disruption of the mitochondrial membranes [D. Sambasivarao & V. Sitaramam (1985), Biochim Biophys Acta, 806, 195-209]. Phosphate- and arsenate-induced swelling was investigated in mitochondria to evaluate the role of phosphate transport in the instability created in the mitochondrial membranes. Phosphate-induced swelling in respiring mitochondria was similar to spontaneous swelling. Both represent essentially colloidal swelling due to the variable porosity induced in the inner membrane to polyols by respiration. Swelling of non-respiring mitochondria at high ammonium phosphate concentrations was, on the other hand, primarily due to high permeability to phosphate. This membrane instability created by phosphate transport in the surrounding lipid involves neither the endogenous nor the exogenous Ca2+.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Consumo de Oxígeno
/
Fosfatos
/
Ratas
/
Sacarosa
/
Mitocondrias Hepáticas
/
Membranas Intracelulares
/
Animales
/
Manitol
/
Dilatación Mitocondrial
Idioma:
Inglés
Revista:
Indian J Biochem Biophys
Año:
1992
Tipo del documento:
Artículo
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