Role of corticosteroids in the management of chronic obstructive lung disease: factors predicting response.
Indian J Chest Dis Allied Sci
;
1992 Jan-Mar; 34(1): 11-7
Artículo
en Inglés
| IMSEAR
| ID: sea-29509
ABSTRACT
A double-blind crossover trial of prednisolone was conducted in 70 patients of chronic obstructive lung disease (COLD). Emphysema dominated the clinical picture in 38, rest being chronic bronchitis with varying degrees of air trapping. None of the patients had clinical asthma. All the patients had obtained maximal benefit from an optimal dose of bronchodilators prior to entering the study. Prednisolone in a dose of 0.8 mg/kg was prescribed in a double blind crossover manner with identical appearing placebo tablets. Patients were evaluated on a weekly basis for an objective as well as a subjective response and side effects of therapy. Thirty-four patients demonstrated a statistically significant improvement in pulmonary functions. In 20 others only subjective response was observed. A good objective response was predicted by a pre-study variability in FEV1, disease duration of less than 10 years and a history of smoking less than 50 pack years.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Enfisema Pulmonar
/
Pruebas de Función Respiratoria
/
Factores de Tiempo
/
Bronquitis
/
Femenino
/
Humanos
/
Masculino
/
Prednisolona
/
Fumar
/
Volumen Espiratorio Forzado
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Chest Dis Allied Sci
Año:
1992
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS