Antituberculosis drug resistance and associated risk factors in the European section of Turkey.
Indian J Chest Dis Allied Sci
;
2004 Jul-Sep; 46(3): 171-7
Artículo
en Inglés
| IMSEAR
| ID: sea-29886
ABSTRACT
BACKGROUND:
We carried out this study in order to establish the prevalence of antituberculosis drug resistance in Mycobacterium tuberculosis strains and to determine risk factors for the development of resistance in Trakya region of Turkey.METHODS:
Pattern of drug resistance in 214 M. tuberculosis isolates from patients with tuberculosis treated at the regional tuberculosis dispensaries were included in the study.RESULTS:
Isolates of 105 (49.1%) were resistant to only one drug, and 62 (29.0%) were resistant to more than one drug. The total resistance rates to streptomycin, isoniazid, rifampicin, ethambutol and isoniazid + rifampicin were 29.0%, 27.1%, 21.5%, 10.3% and 11.6%, respectively. The secondary resistance rates in all drugs and combinations were higher than primary resistance rates (p<0.001). Step wise logistic regression revealed that (i) non-compliance with treatment increases the chances of development of resistance by 15 times [p<0.00001, 95% confidence intervals (95% CI) 4.16 to 56.70], and (ii) a regimen of inadequate treatment increases the chance of development of drug resistance by 10.5 times (p<0.01, 95% CI=2.66 to 49.80).CONCLUSIONS:
We propose that specially trained physicians should institute antituberculosis therapy and medication should be practiced under direct observation in this region.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tuberculosis Pulmonar
/
Turquía
/
Anciano de 80 o más Años
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Pruebas de Sensibilidad Microbiana
/
Niño
/
Preescolar
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Aged80
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Chest Dis Allied Sci
Año:
2004
Tipo del documento:
Artículo
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