A prospective study of sensitivity and specificity of adenosine deaminase estimation in the diagnosis of tuberculosis pleural effusion.
Indian J Chest Dis Allied Sci
;
2001 Jul-Sep; 43(3): 149-55
Artículo
en Inglés
| IMSEAR
| ID: sea-30230
ABSTRACT
We prospectively evaluated the usefulness of adenosine deaminase [ADA] estimation in the diagnosis of tuberculosis [TB] pleural effusion. Seventy five subjects with pleural effusion were studied. Forty eight of them had TB pleural effusion [MF 3711; mean age 33 +/- 14.4 years range 17-76] and the remaining 27 had pleural effusion due to causes other than TB [non-TB group] [MF 198; mean age 47.3 +/- 16.5 years; range 17-75]. Pleural fluid [PF] ADA levels were significantly higher in TB (n=48; mean 95.8 +/- 57.5 IU/L) compared with non-TB group (n=27; mean 30.7 +/- 27.2 IU/L) [p<0.001]. Serum ADA [S-ADA] levels were also significantly higher in TB (n=45; mean 39.6 +/- 18.3 IU/L) compared with non-TB group (n=26; mean 18.0 +/- 13.7 IU/L) [p<0.001]. PF-ADA levels were higher compared to S-SDA in TB (p <0.001) and non-TB groups [p<0.01]. Using a cut off of 35 IU/L, the sensitivity and specificity of PF-ADA in the diagnosis of TB was computed to be 83.3% and 66.6% respectively. At a cut-off level of 100 IU/L, PF-ADA was found to have a sensitivity 40% and specificity 100%. From this study it is concluded that, using 100 IU/L as the cut-off, it is possible to avoid pleural biopsy to ascertain the diagnosis of TB in as much as 40% of the patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Derrame Pleural
/
Tuberculosis Pleural
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Adenosina Desaminasa
/
Estudios Prospectivos
/
Análisis de Varianza
/
Sensibilidad y Especificidad
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Chest Dis Allied Sci
Año:
2001
Tipo del documento:
Artículo
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