Antimalarial and toxic effect of triple combination of pyronaridine, sulfadoxine and pyrimethamine.
Southeast Asian J Trop Med Public Health
;
1989 Jun; 20(2): 257-63
Artículo
en Inglés
| IMSEAR
| ID: sea-30867
ABSTRACT
The triple combination of pyronaridine, sulfadoxine and pyrimethamine which has been proven to be efficient in delaying emergence of drug resistance of rodent malarial parasites was further studied for potential application to malaria control. The antimalarial effect of the triple combination on Plasmodium berghei ANKA-infected mice and the toxic effects in mice and rats were additive. A single dose of pyronaridine 500 mg in combination with sulfadoxine, 1000 or 1500 mg, and pyrimethamine, 50 or 75 mg, given to 72 acute falciparum malaria patients resulted in a 100% cure rate with nil or mild side effects, and no recrudescence of asexual parasite over 4-week follow-up. Preliminary experiments on the drug effect on sporogony showed that the drug combination at the dose used could not completely interrupt the sporozoite formation although many retarded oocysts were found.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Plasmodium falciparum
/
Pirimetamina
/
Ratas
/
Sulfadoxina
/
Sulfanilamidas
/
Humanos
/
Estudios de Seguimiento
/
Quimioterapia Combinada
/
Animales
/
Malaria
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1989
Tipo del documento:
Artículo
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