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Four is better than nine. a combined diphtheria-tetanus-pertussis-hepatitis B-Haemophilus influenzae type b vaccine for routine immunization in Malaysia.
Southeast Asian J Trop Med Public Health ; 2008 May; 39(3): 474-83
Artículo en Inglés | IMSEAR | ID: sea-30902
ABSTRACT
Malaysian infants would have to receive nine injections during the first few months of life in order to be protected against disease caused by hepatitis B (HBV), diphtheria, tetanus, pertussis and Haemophilus influenzae type b (Hib) if single HBV and Hib vaccines were used. We evaluated a combined DTPw-HBV/Hib vaccine administered at 1.5, 3 and 5 months after a birth dose of hepatitis B vaccine (HBV). One month after completion of the primary vaccination, 99% of subjects had seroprotective anti-HBV antibody levels, and at least 98% had seroprotective antibodies against diphtheria, tetanus, and Hib, and were seropositive for pertussis antibodies. The immune response to the combined vaccine was comparable to that induced by separate injections with DTPw, HBV and Hib vaccines. Overall, the DTPw-HBV/Hib vaccine was as well tolerated as separate administration of DTPw, HBV and Hib vaccines. The combined DTPw-HBV/Hib vaccine induces protection against five diseases as recommended in the Malaysian routine vaccination schedule. Use of the combined DTPw-HBV/Hib vaccine can reduce the required number of injections from nine to four in the first few months of life.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Humanos / Recién Nacido / Ensayo de Inmunoadsorción Enzimática / Radioinmunoensayo / Vacuna contra Difteria, Tétanos y Tos Ferina / Esquemas de Inmunización / Vacunas contra Hepatitis B / Vacunas Conjugadas / Vacunas Combinadas / Vacunas contra Haemophilus Tipo de estudio: Ensayo Clínico Controlado País/Región como asunto: Asia Idioma: Inglés Revista: Southeast Asian J Trop Med Public Health Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Humanos / Recién Nacido / Ensayo de Inmunoadsorción Enzimática / Radioinmunoensayo / Vacuna contra Difteria, Tétanos y Tos Ferina / Esquemas de Inmunización / Vacunas contra Hepatitis B / Vacunas Conjugadas / Vacunas Combinadas / Vacunas contra Haemophilus Tipo de estudio: Ensayo Clínico Controlado País/Región como asunto: Asia Idioma: Inglés Revista: Southeast Asian J Trop Med Public Health Año: 2008 Tipo del documento: Artículo