Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones.
Southeast Asian J Trop Med Public Health
;
2006 Jul; 37(4): 607-12
Artículo
en Inglés
| IMSEAR
| ID: sea-31224
ABSTRACT
Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Plasmodium falciparum
/
Estructura Molecular
/
Cloroquina
/
Ácido Aspártico Endopeptidasas
/
Concentración 50 Inhibidora
/
Chalconas
/
Animales
/
Antimaláricos
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
2006
Tipo del documento:
Artículo
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