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Pulmonary microthromboembolism by injection of sonicated autologous blood in rabbits with splenic artery ligations.
Southeast Asian J Trop Med Public Health ; 1997 ; 28 Suppl 3(): 138-40
Artículo en Inglés | IMSEAR | ID: sea-31554
ABSTRACT
Chronic pulmonary thromboembolism (PTE) has been reported to play an important role in cardiac failure in thalassemic patients after splenectomy. However, the mechanism of PTE in these patients remains unclear. In this study, we attempted to establish an animal model of PTE seen in thalassemic patients after splenectomy. We divided New Zealand white rabbits into three groups Group 1 was injected sonicated blood, II was injected non-sonicated blood after ligation of the splenic artery, and III was injected sonicated blood after ligation of the splenic artery. After injection of the sonicated blood, we counted the platelet number until 1 hour and the rabbits were sacrificed for histological examination. Platelets significantly decreased in number immediately after injection of the sonicated blood in Groups I and III. Many pulmonary thromboemboli composed mainly of platelets were found in Group III but not in other groups. These pathological changes seem to be partly similar to those of thalassemic patients after splenectomy. This animal model is thought to be useful to study the pathogenesis of pulmonary thromboembolism, especially in thalassemic patients after splenectomy.
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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Recuento de Plaquetas / Embolia Pulmonar / Conejos / Sonicación / Esplenectomía / Arteria Esplénica / Talasemia / Humanos / Masculino / Modelos Animales de Enfermedad Idioma: Inglés Revista: Southeast Asian J Trop Med Public Health Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Recuento de Plaquetas / Embolia Pulmonar / Conejos / Sonicación / Esplenectomía / Arteria Esplénica / Talasemia / Humanos / Masculino / Modelos Animales de Enfermedad Idioma: Inglés Revista: Southeast Asian J Trop Med Public Health Año: 1997 Tipo del documento: Artículo