Response of patients with bleeding disorder to DDAVP administration.
Southeast Asian J Trop Med Public Health
;
1993 ; 24 Suppl 1(): 174-9
Artículo
en Inglés
| IMSEAR
| ID: sea-31724
ABSTRACT
DDAVP has been shown to provide hemostasis in patients with bleeding disorder. Thirty-one episodes of intravenous DDAVP administration (0.3-0.4 microgram/kg) in 22 patients with bleeding disorder were studied. There were 13 patients with hemophilia A, 1 with type I vWD and 8 with inherited and acquired platelet dysfunction. The age ranged from 2.3-26 yrs (mean +/- SD = 10 +/- 4.8). None of the 3 severe hemophilia A patients responded to the treatment. Two out of five episodes in 4 moderate hemophilia A patients responded clinically and had minute increments of F VIIIC. Ten out of eleven episodes (91%) in 6 mild hemophilia A patients had good responses. The dental procedures for these patients were successfully performed without blood component transfusion. The increments of F VIIIC ranged from 1.5-6.8 folds over the baseline levels (mean +/- SD = 2.5 +/- 1.4). In addition, two episodes of epistaxis in a vWD patient responded excellently and one dental procedure was successfully performed by giving DDAVP. The increments of F VIIIC and vWFAg ranged from 2.8-12.5 and 2.9-8 fold over the baseline levels respectively. The prolonged bleeding times were shorten to 6.5-7 minutes. Only three out of eight episodes in 8 inherited and acquired platelet dysfunction patients showed temporary responses. The bleeding time responses did not correlate with in vitro platelet aggregation.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Enfermedades de von Willebrand
/
Pruebas de Coagulación Sanguínea
/
Trastornos de las Plaquetas Sanguíneas
/
Infusiones Intravenosas
/
Humanos
/
Niño
/
Preescolar
/
Adolescente
/
Resultado del Tratamiento
/
Costos de los Medicamentos
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1993
Tipo del documento:
Artículo
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