Prevalence of polymorphisms in DHFR, DHPS, PFMDR1 and PFCRT genes of Plasmodium falciparum isolates in Quang Tri Province, Vietnam.
Southeast Asian J Trop Med Public Health
;
2008 Nov; 39(6): 959-62
Artículo
en Inglés
| IMSEAR
| ID: sea-31793
ABSTRACT
In 2002 an antimalarial drug resistance survey was carried out in a seasonally endemic area of Vietnam. Sulfadoxine/pyrimethamine (S/P) was the standard treatment recommended for uncomplicated Plasmodium falciparum malaria in that area at the time. Early or late treatment failure as defined by WHO was observed in 14.9% (7/47) of patients. Molecular analysis of treatment failure isolates identified that 5/6 carried two or more dhfr and dhps polymorphisms associated with S/P resistance. Chloroquine resistance-associated polymorphisms occurred in 38.5% (15/39) of the isolates. These results support the move to artemisinin-based combination therapy for malaria in Vietnam.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Plasmodium falciparum
/
Polimorfismo Genético
/
Pirimetamina
/
Sulfadoxina
/
Vietnam
/
Femenino
/
Humanos
/
Masculino
/
Resistencia a Medicamentos
/
Proteínas Protozoarias
Tipo de estudio:
Estudio de prevalencia
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
2008
Tipo del documento:
Artículo
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