Features of Schistosoma mansoni infection in SCID mice.
Southeast Asian J Trop Med Public Health
;
1997 Dec; 28(4): 838-43
Artículo
en Inglés
| IMSEAR
| ID: sea-32098
ABSTRACT
Features of Schistosoma mansoni infection in SCID mice, which lack functional T- and B-lymphocytes, were investigated. The retarded development of parasites as well as reduction of liver egg recovery in SCID mice was significantly lower than those in congenic counterpart C.B-17 mice. Furthermore, the rate of parasite recovery from SCID mice with primary infection was always lower than that from C.B-17 mice by 20%, showing the innate resistance to S. mansoni infection. SCID mice vaccinated with UV-attenuated S. mansoni cercariae did not show protective immunity against a homologous challenge infection. The present innate resistance exhibited in SCID mice is discussed in relation to cell mediated immunity of macrophage activation by IFN-gamma which would not involve T-lymphocytes but is initiated by IL-12 and TNF-alpha cytokines. SCID mice may provide novel information on the host-parasite relationship in schistosome infections.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Schistosoma mansoni
/
Factores de Tiempo
/
Esquistosomiasis mansoni
/
Femenino
/
Masculino
/
Ratones SCID
/
Interacciones Huésped-Parásitos
/
Animales
/
Ratones
/
Ratones Endogámicos
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1997
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS