Detection of BCR/ABL fusion gene in CML: a preliminary report.
Southeast Asian J Trop Med Public Health
;
1995 ; 26 Suppl 1(): 197-200
Artículo
en Inglés
| IMSEAR
| ID: sea-32225
ABSTRACT
The BCR/ABL fusion gene in 31 patients with chronic myeloid leukemia (CML) was detected by RT/PCR. In 18 cases of Ph' positive patients, 13 had BCR 3/ABL II rearrangement, 1 had BCR 2/ABL II rearrangement and 4 had both rearrangements. One case with complex translocation 46,XY,t(9;9;22), had BCR 3/ABL II rearrangement. In 8 cases of Ph' negative patients, 4 had BCR 3/ABL II rearrangement, 3 had both rearrangements while 1 had no BCR/ABL rearrangement. Interestingly, in 4 patients who had no cytogenetic result, we could observe BCR 3/ABL II rearrangement in 3 cases and both rearrangements in 1 case. The results suggest that this procedure is sensitive and independent of the presence or absence of an identifiable Ph' chromosome.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Transcripción Genética
/
Médula Ósea
/
Cromosoma Filadelfia
/
Femenino
/
Humanos
/
Masculino
/
Reordenamiento Génico
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Reacción en Cadena de la Polimerasa
/
Exones
Tipo de estudio:
Estudio diagnóstico
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1995
Tipo del documento:
Artículo
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