Structure-activity relationships of dengue antiviral polycyclic quinones.
Southeast Asian J Trop Med Public Health
;
2005 Jul; 36(4): 901-5
Artículo
en Inglés
| IMSEAR
| ID: sea-32284
ABSTRACT
The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Hidrocarburos Policíclicos Aromáticos
/
Quinonas
/
Relación Estructura-Actividad
/
Estructura Molecular
/
Virus del Dengue
/
Animales
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
2005
Tipo del documento:
Artículo
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