Levamisole and mebendazole in the treatment of bancroftian infection.
Southeast Asian J Trop Med Public Health
;
1978 Dec; 9(4): 571-5
Artículo
en Inglés
| IMSEAR
| ID: sea-32515
ABSTRACT
Levamisole and mebendazole, broad spectrum anthelminthic compounds were tested against microfilaria of Wuchereria bancrofti, and the results were compared with similarly treated diethylcarbamazine and untreated group. Levamisole at a dosage of 3 mg/kg daily for 8 days showed marked reduction in both microfilaria rate and microfilaria density and immediately thereafter mf-rate steadily increased almost up to pre-treatment level, the mf-density however showed only marginal increase. Mebendazole at dosage of 6 mg/kg daily for 10 days following 8 days treatment of levamisole also showed marginal increase of mf-rate but no increase of mf-density. Treatment with DEC at a dosage of 6 mg/kg daily for 12 days showed comparatively better results both in respect of reduction in mf-rate and mf-density. The reactions - severity and duration were more among levamisole treated groups as compared to DEC treated group. Thus with the dosages tried, DEC could be considered as a better drug than levamisole and mebendazole. Both the latter compounds had no or very limited effect on the adult worms of W. bancrofti.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Placebos
/
Wuchereria bancrofti
/
Bencimidazoles
/
Humanos
/
Levamisol
/
Dietilcarbamazina
/
Filariasis
/
Mebendazol
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1978
Tipo del documento:
Artículo
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