Your browser doesn't support javascript.
loading
Effects of human alpha, beta and gamma interferons on varicella zoster virus in vitro.
Southeast Asian J Trop Med Public Health ; 1994 Jun; 25(2): 252-7
Artículo en Inglés | IMSEAR | ID: sea-32562
ABSTRACT
The antiviral effects of interferon (IFN) on varicella zoster virus (VZV) and herpes simplex virus (HSV) in vitro were examined. The values for the 50% inhibitory dose (ID50) of IFN-alpha, beta and gamma determined by plaque reduction assay, were 0.813, 0.650 and 13.750 IU/ml, respectively, against VZV and 18.00, 10.38 and 115.0 IU/ml, respectively, against HSV. Thus IFN-alpha and beta were more effective than IFN-gamma against both VZV and HSV and VZV was more sensitive than HSV to the IFNs. Five mutants of VZV which were resistant to acyclovir (ACV), phosphonoacetic acid (PAA) or bromodeoxyuridine (BUDR) were also sensitive to IFN beta, their average ID50 being 1.31 IU/ml. Analysis of virus-specific proteins by the immunofluorescent technique with various antisera showed that IFN had a significant effect before early protein synthesis.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ensayo de Placa Viral / Factores de Tiempo / Cultivo de Virus / Humanos / Farmacorresistencia Microbiana / Células Cultivadas / Técnica del Anticuerpo Fluorescente / Interferón gamma / Interferón beta / Interferón-alfa Idioma: Inglés Revista: Southeast Asian J Trop Med Public Health Año: 1994 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ensayo de Placa Viral / Factores de Tiempo / Cultivo de Virus / Humanos / Farmacorresistencia Microbiana / Células Cultivadas / Técnica del Anticuerpo Fluorescente / Interferón gamma / Interferón beta / Interferón-alfa Idioma: Inglés Revista: Southeast Asian J Trop Med Public Health Año: 1994 Tipo del documento: Artículo