Appearance of adherent cells suppressive to erythropoiesis during an early stage of Plasmodium berghei infection in mice.
Southeast Asian J Trop Med Public Health
;
1992 Jun; 23(2): 184-8
Artículo
en Inglés
| IMSEAR
| ID: sea-32785
ABSTRACT
We examined the effect of adherent cells from bone marrow or spleen of mice infected with Plasmodium berghei on dyserythropoiesis. Significant reduction in number of erythroid progenitors (erythroid colony-forming units CFU-E and erythroid burst-forming units BFU-E) was observed in bone marrow as early as 1 day after P. berghei infection. When adherent cells were removed from bone marrow or spleen cells of infected mice, the number of CFU-E and BFU-E was clearly increased. Furthermore, addition of adherent cells from infected mice to nonadherent cells from normal mice inhibited erythroid colony formation significantly in a dose-dependent manner. These results suggest that the adherent cells obtained from bone marrow or spleen of mice in the early stage of P. berghei-infection have a suppressive effect on erythropoiesis.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Plasmodium malariae
/
Bazo
/
Femenino
/
Humanos
/
Células de la Médula Ósea
/
Células Precursoras Eritroides
/
Factores Supresores Inmunológicos
/
Eritropoyesis
/
Lactante
/
Animales
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1992
Tipo del documento:
Artículo
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